A randomised double-blind, cross-over trial of 4-aminopyridine for downbeat nystagmus--effects on slowphase eye velocity, postural stability, locomotion and symptoms.

Abstract

OBJECTIVE The effects of 4-aminopyridine (4-AP) on downbeat nystagmus (DBN) were analysed in terms of slow-phase velocity (SPV), stance, locomotion, visual acuity (VA), patient satisfaction and side effects using standardised questionnaires. METHODS Twenty-seven patients with DBN received 5 mg 4-AP four times a day or placebo for 3 days and 10 mg 4-AP… (More)
DOI: 10.1136/jnnp-2012-304736

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@article{Claassen2013ARD, title={A randomised double-blind, cross-over trial of 4-aminopyridine for downbeat nystagmus--effects on slowphase eye velocity, postural stability, locomotion and symptoms.}, author={Jens Claassen and Rainer Spiegel and Roger Kalla and Mary Catherine Faldon and Christopher Kennard and Chotipat Danchaivijitr and Stanislaw Bardins and Nicole Rettinger and Erich Schneider and Thomas Brandt and Klaus Jahn and Julian Teufel and Michael Strupp and Adolfo Bronstein}, journal={Journal of neurology, neurosurgery, and psychiatry}, year={2013}, volume={84 12}, pages={1392-9} }