A randomised double‐blind study comparing the effect of 1072‐nm light against placebo for the treatment of herpes labialis

@article{Hargate2006ARD,
  title={A randomised double‐blind study comparing the effect of 1072‐nm light against placebo for the treatment of herpes labialis},
  author={G Hargate},
  journal={Clinical and Experimental Dermatology},
  year={2006},
  volume={31}
}
  • G. Hargate
  • Published 1 September 2006
  • Medicine
  • Clinical and Experimental Dermatology
Background.  Previous research demonstrated that 1072‐nm narrowband laser light is effective in the treatment of cold sores. 
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References

SHOWING 1-10 OF 25 REFERENCES
A pilot study of treatment of herpes labialis with 1072 nm narrow waveband light
TLDR
It is demonstrated that a single 5 min light treatment significantly reduced cold sore healing time by 4“days; 1072 nm light healed cold sores in 4.3 ± 1.8 days (mean ± SD) as compared with aciclovir applied five times daily, 8.5‰±‰3.0‰days (P < 0.0001).
Acyclovir Cream for Treatment of Herpes Simplex Labialis: Results of Two Randomized, Double-Blind, Vehicle-Controlled, Multicenter Clinical Trials
TLDR
Acyclovir cream did not prevent the development of classical lesions (progression to vesicles, ulcers, and/or crusts) and there was a statistically significant reduction in the duration of lesion pain in both studies.
The natural history of ultraviolet radiation-induced herpes simplex labialis and response to therapy with peroral and topical formulations of acyclovir.
TLDR
ACV therapy can be efficacious, but some rapidly developing lesions are unresponsive to treatment, which suggests that more than one process may contribute to the pathogenesis of herpes labialis.
Improvement of host response to sepsis by photobiomodulation
TLDR
Whether laser irradiation has a stimulatory effect on the immune response in sepsis using an animal model is determined and ATP‐MgCL2 appears to improve cellular energetics and decrease mortality.
Cross-sectional study of recurrent herpes labialis. Prevalence and risk factors.
Consecutive blood donors at 25 sites in southern Wisconsin were interviewed in 1985 to ascertain recurrent herpes labialis histories, other perioral conditions, and status on possible predisposing
Treatment modalities and medication recommended by health care professionals for treating recurrent herpes labialis.
TLDR
Variation in treatment modalities and recommendations by each health profession is found, despite the fact that patients reported similar triggers and concerns, according to individual patient need and health care professional's lack of knowledge.
Laser modulation of human immune system: Inhibition of lymphocyte proliferation by a gallium‐arsenide laser at low energy
TLDR
The results indicate that laser irradiation at low energy can interfere with immune system in vitro, and similar modulation could potentially occur in human subjects exposed to laser irradiated in vivo.
[The effect of infrared laser rays on herpes simplex virus and the functions of human immunocompetent cells].
In vitro investigations were performed to study the effect of infrared Nd:YAG laser irradiation on herpes simplex virus and the viral replication in herpes-infected Vero cell microcultures. In
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