A randomised controlled trial with prolonged-release oral oxycodone and naloxone to prevent and reverse opioid-induced constipation.

@article{Meissner2009ARC,
  title={A randomised controlled trial with prolonged-release oral oxycodone and naloxone to prevent and reverse opioid-induced constipation.},
  author={Winfried Meissner and Petra Leyendecker and Stefan Mueller-Lissner and Joachim Nadstawek and Michael Hopp and Christian Ruckes and Stefan Wirz and Wolfgang Fleischer and Karen Reimer},
  journal={European journal of pain},
  year={2009},
  volume={13 1},
  pages={56-64}
}
BACKGROUND Opioid-induced constipation can have a major negative impact on patients' quality of life. This randomised, double-blinded study evaluated the analgesic efficacy of prolonged-release (PR) oral oxycodone when co-administered with PR oral naloxone, and its impact on opioid-induced constipation in patients with severe chronic pain. Another objective was to identify the optimal dose ratio of oxycodone and naloxone. METHODS A total of 202 patients with chronic pain (mainly non-cancer… CONTINUE READING

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