A randomised, prospective, double-blind, placebo-controlled trial of glyceryl trinitrate ointment in treatment of anal fissure

@article{Lund1997ARP,
  title={A randomised, prospective, double-blind, placebo-controlled trial of glyceryl trinitrate ointment in treatment of anal fissure},
  author={J. Lund and J. Scholefield},
  journal={The Lancet},
  year={1997},
  volume={349},
  pages={11-14}
}
BACKGROUND Anal fissure is most commonly treated surgically by internal anal sphincterotomy. However, there is some concern over the effects of this procedure on continence. Nitric oxide donors such as glyceryl trinitrate (GTN) have been shown to cause a reversible chemical sphincterotomy capable of healing fissures in a small series of cases. This study reports a prospective, randomised, double-blind, placebo-controlled trial to test the hypothesis that topical GTN is the best first-line… Expand
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Paper Mentions

Interventional Clinical Trial
Autologous PRP currently has many uses in surgical and medical therapy. Compared with other regenerative therapies, PRP is easy-to-prepare, low-cost, and does not require complex… Expand
ConditionsAnal Fissure Chronic, PRP
InterventionBehavioral, Biological, Dietary Supplement, (+1 more)
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