A randomised, double-blind, sham-controlled study of granulocyte/monocyte apheresis for moderate to severe Crohn's disease.

@article{Sands2013ARD,
  title={A randomised, double-blind, sham-controlled study of granulocyte/monocyte apheresis for moderate to severe Crohn's disease.},
  author={Bruce E Sands and Seymour Katz and D. Wolf and Brian G Feagan and Tao Wang and Lisa-Marie Gustofson and Cindy J. Wong and Margaret K. Vandervoort and Stephen Hanauer},
  journal={Gut},
  year={2013},
  volume={62 9},
  pages={1288-94}
}
OBJECTIVES Activated granulocytes and monocytes may contribute to the pathogenesis of Crohn's disease (CD). In small, uncontrolled studies, granulocyte/monocyte apheresis (GMA) has shown promise in treating CD. We conducted a randomised, double-blind study to compare GMA with a sham procedure in patients with moderate to severe CD. DESIGN Patients with active CD as defined by a Crohn's Disease Activity Index (CDAI) of 220-450 were randomly allocated in a 2:1 ratio to treatment with GMA using… CONTINUE READING
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References

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A randomized , double - blind , sham - controlled study of granulocyte / monocyte apheresis for active ulcerative colitis

  • WR Best, JM Becktel, JW Singleton
  • Gastroenterology
  • 2008

Oxidative stress , in fl ammation and neutrophil superoxide release in patients with Crohn ’ s disease : distinction between active and non - active disease

  • AR Saniabadi, H Hanai, K Takeuchi
  • Dig Dis Sci
  • 2008

New technique of leukocytapheresis by the use of nonwoven polyester fi ber fi lter for in fl ammatory bowel disease

  • A Kawamura, M Saitoh, M Yonekawa
  • Ann Intern Med
  • 2007

Adalimumab induction therapy for Crohn ’ s disease previously treated with In fl iximab

  • WJ Sandborn, P Rutgeerts, R Enns
  • In fl amm Bowel Dis
  • 2006

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