A randomised, double-blind, placebo-controlled trial of a recombinant version of human α-fetoprotein (MM-093) in patients with active rheumatoid arthritis

@article{Pollard2007ARD,
  title={A randomised, double-blind, placebo-controlled trial of a recombinant version of human $\alpha$-fetoprotein (MM-093) in patients with active rheumatoid arthritis},
  author={L. Pollard and J. Murray and M. Moody and E. Stewart and E. Choy},
  journal={Annals of the Rheumatic Diseases},
  year={2007},
  volume={66},
  pages={687 - 689}
}
Background: Rheumatoid arthritis (RA) tends to remit during pregnancy, with more patients achieving remission in the third trimester, coinciding with an increase in levels of α-fetoprotein (AFP). In vitro and animal studies have shown that AFP has immunomodulatory properties. MM-093 is a non-glycosylated, recombinant version of human AFP. Objective: To assess the safety, tolerability and clinical effects of MM-093 during a 12-week, randomised, double-blind, placebo-controlled study. Methods: 12… Expand
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