A random-walk/giant-loop model for interphase chromosomes.

  title={A random-walk/giant-loop model for interphase chromosomes.},
  author={Rainer K. Sachs and Ger van den Engh and Barbara J. Trask and Hisao A Yokota and J. E. Hearst},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={92 7},
Fluorescence in situ hybridization data on distances between defined genomic sequences are used to construct a quantitative model for the overall geometric structure of a human chromosome. We suggest that the large-scale geometry during the G0/G1 part of the cell cycle may consist of flexible chromatin loops, averaging approximately 3 million bp, with a random-walk backbone. A fully explicit, three-parametric polymer model of this random-walk/giant-loop structure can account well for the data… CONTINUE READING
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