A random effect model for reconstruction of spatial chromatin structure.

@article{Park2017ARE,
  title={A random effect model for reconstruction of spatial chromatin structure.},
  author={Jincheol Park and Shili Lin},
  journal={Biometrics},
  year={2017},
  volume={73 1},
  pages={52-62}
}
A gene may be controlled by distal enhancers and repressors, not merely by regulatory elements in its promoter. Spatial organization of chromosomes is the mechanism that brings genes and their distal regulatory elements into close proximity. Recent molecular techniques, coupled with Next Generation Sequencing (NGS) technology, enable genome-wide detection of physical contacts between distant genomic loci. In particular, Hi-C is an NGS-aided assay for the study of genome-wide spatial… CONTINUE READING

Citations

Publications citing this paper.

References

Publications referenced by this paper.
Showing 1-10 of 23 references

Bayesian Inference of Spatial Organizations of Chromosomes

PLoS Computational Biology • 2013
View 14 Excerpts
Highly Influenced

A Bayesian mixture model for chromatin interaction data.

Statistical applications in genetics and molecular biology • 2015
View 2 Excerpts

Revised March 2016

Received November
Accepted April 2016. • 2015

Statistical Inference on Three - Dimensional Structure of Genome by Truncated Poisson Architecture Model

J. Park, S. Lin
2015
View 1 Excerpt

Statistical Inference on ThreeDimensional Structure of Genome by Truncated Poisson Architecture Model. In Ordered Data Analysis, Modeling, and Health Research Methods

J. Park, S. Lin
In Honor of H. N. Nagaraja’s 60th Birthday • 2015
View 1 Excerpt

Similar Papers

Loading similar papers…