A raf-independent epidermal growth factor receptor autocrine loop is necessary for Ras transformation of rat intestinal epithelial cells.

@article{Gangarosa1997ARE,
  title={A raf-independent epidermal growth factor receptor autocrine loop is necessary for Ras transformation of rat intestinal epithelial cells.},
  author={Lisa M Gangarosa and Nywana S Sizemore and Ramona Graves-Deal and Sean M Oldham and Channing J Der and Robert J Coffey},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 30},
  pages={18926-31}
}
We recently have shown that activated Ras, but not Raf, causes transformation of intestinal (RIE-1, IEC-6) epithelial cells, whereas both activated Ras and Raf transform NIH 3T3 fibroblasts (Oldham, S. M., Clark, G. J., Gangarosa, L. M., Coffey, R. J., and Der, C. J. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 6924-6928). The observations that conditioned medium from Ras-, but not Raf-, transfected RIE-1 cells, as well as exogenous transforming growth factor alpha (TGFalpha), promoted… CONTINUE READING

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