A radiotracer method for the measurement of central nervous system catecholamines in vivo.

Abstract

A new strategy for measurement of brain catecholamines was tested in an animal model. [3H]Norepinephrine was infused intravenously in rabbits to label the peripheral norepinephrine pools. The specific activity of urinary 3-methoxy-4-hydroxymandelic acid was consistently higher than that for 3-methoxy-4-hydroxyphenyglycol (MHPG). Central sympathectomy with 6-hydroxydopamine abolished this difference. Using the formula we propose, it is estimated that 30-50% of urinary MHPG originates from the central nervous system.

Cite this paper

@article{Tang1978ARM, title={A radiotracer method for the measurement of central nervous system catecholamines in vivo.}, author={Siu Wa Tang and Harvey C. Stancer and Jerry J. Warsh}, journal={Canadian journal of physiology and pharmacology}, year={1978}, volume={56 3}, pages={535-8} }