A radicicol-related macrocyclic nonaketide compound, antibiotic LL-Z1640-2, inhibits the JNK/p38 pathways in signal-specific manner.

@article{Takehana1999ARM,
  title={A radicicol-related macrocyclic nonaketide compound, antibiotic LL-Z1640-2, inhibits the JNK/p38 pathways in signal-specific manner.},
  author={Kenji Takehana and Shigeru Sato and Takasi Kobayasi and Toshinaga Maeda},
  journal={Biochemical and biophysical research communications},
  year={1999},
  volume={257 1},
  pages={
          19-23
        }
}
Macrocyclic nonaketide compounds, radicicol and its two analogues, 87-250904-F1 and LL-Z1640-2, have various biological activities. Here we show that these compounds inhibit signal-dependent transcriptional activation with different specificity with distinct mechanism. Although all three compounds inhibited PMA-induced AP-1 transcriptional activity in cell-based reporter assay, these compounds exhibited differential effects in separate transcriptional reporter assays for NF-kappaB and… CONTINUE READING
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