A radical explanation for glucose-induced beta cell dysfunction.

  title={A radical explanation for glucose-induced beta cell dysfunction.},
  author={Michael Brownlee},
  journal={The Journal of clinical investigation},
  volume={112 12},
The development of type 2 diabetes requires impaired beta cell function. Hyperglycemia itself causes further decreases in glucose-stimulated insulin secretion. A new study demonstrates that hyperglycemia-induced mitochondrial superoxide production activates uncoupling protein 2, which decreases the ATP/ADP ratio and thus reduces the insulin-secretory response. These data suggest that pharmacologic inhibition of mitochondrial superoxide overproduction in beta cells exposed to hyperglycemia could… CONTINUE READING
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