A quorum sensing-associated virulence gene of Pseudomonas aeruginosa encodes a LysR-like transcription regulator with a unique self-regulatory mechanism.

@article{Cao2001AQS,
  title={A quorum sensing-associated virulence gene of Pseudomonas aeruginosa encodes a LysR-like transcription regulator with a unique self-regulatory mechanism.},
  author={Hong Long Cao and Gayathri Krishnan and Boyan C. Goumnerov and John Tsongalis and Ronald K. Tompkins and Laurence G Rahme},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 25},
  pages={
          14613-8
        }
}
The human opportunistic pathogen Pseudomonas aeruginosa strain PA14 infects both plants and animals. Previously, using plants to screen directly for P. aeruginosa virulence-attenuated mutants, we identified a locus, pho34B12, relevant in mammalian pathogenesis. Here, nonsense point mutations in the two opposing ORFs identified in the pho34B12 locus revealed that one of them, mvfR (multiple virulence factor Regulator), is able to control all of the phenotypes that mutant phoA34B12 displays. Both… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 136 CITATIONS, ESTIMATED 46% COVERAGE

The hierarchy quorum sensing network in Pseudomonas aeruginosa

  • Protein & Cell
  • 2014
VIEW 11 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Pseudomonas aeruginosa infection of zebrafish involves both host and pathogen determinants.

  • Infection and immunity
  • 2009
VIEW 5 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

The Pseudomonas Quinolone Signal (PQS): Not Just for Quorum Sensing Anymore

  • Front. Cell. Infect. Microbiol.
  • 2018
VIEW 7 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2002
2019

CITATION STATISTICS

  • 22 Highly Influenced Citations

  • Averaged 7 Citations per year over the last 3 years