A quantitative trait locus influences coordinated variation in measures of ApoB-containing lipoproteins.

@article{Rainwater2004AQT,
  title={A quantitative trait locus influences coordinated variation in measures of ApoB-containing lipoproteins.},
  author={David Landry Rainwater and Michael C. Mahaney and John L Vandeberg and Gerome Brush and Laura Almasy and John Blangero and Bennett Dyke and James E. Hixson and S. A. Cole and Jean W Maccluer},
  journal={Atherosclerosis},
  year={2004},
  volume={176 2},
  pages={379-86}
}
Lipoprotein phenotypes are known to be strongly intercorrelated. These intercorrelations are due to genetic and environmental effects on common metabolic pathways. The purpose of this study was to determine if we could localize genes that exert pleiotropic effects on multiple related lipoprotein traits in humans. Using data from the San Antonio Family Heart Study, we extracted principal components from a set of 12 intercorrelated lipoprotein traits that included phenotypes reflecting lipid and… CONTINUE READING