A quantitative test to estimate neutralizing antibodies to the hepatitis C virus: cytofluorimetric assessment of envelope glycoprotein 2 binding to target cells.

@article{Rosa1996AQT,
  title={A quantitative test to estimate neutralizing antibodies to the hepatitis C virus: cytofluorimetric assessment of envelope glycoprotein 2 binding to target cells.},
  author={Domenico Rosa and Susanna Campagnoli and Carlo Moretto and Eric Guenzi and L C Cousens and Motoaki Chin and C K Dong and Amy J. Weiner and Johnson Y. N. Lau and Q L Choo and David M Chien and Piero Pileri and Michael Houghton and Sergio Abrignani},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 5},
  pages={1759-63}
}
Hepatitis C virus (HCV) is a major cause of chronic hepatitis. The virus does not replicate efficiently in cell cultures, and it is therefore difficult to assess infection-neutralizing antibodies and to evaluate protective immunity in vitro. To study the binding of the HCV envelope to cell-surface receptors, we developed an assay to assess specific binding of recombinant envelope proteins to human cells and neutralization thereof. HCV recombinant envelope proteins expressed in various systems… CONTINUE READING
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