A quantitative study of water diffusion in multiple sclerosis lesions and normal-appearing white matter using echo-planar imaging.

@article{Filippi2000AQS,
  title={A quantitative study of water diffusion in multiple sclerosis lesions and normal-appearing white matter using echo-planar imaging.},
  author={Massimo Filippi and Giuseppe Iannucci and Mara Cercignani and M Assunta Rocca and Alessandra Pratesi and G. Comi},
  journal={Archives of neurology},
  year={2000},
  volume={57 7},
  pages={
          1017-21
        }
}
OBJECTIVES We used an optimized echo-planar pulse sequence for isotropically weighted diffusion imaging (1) to measure mean diffusivity (D) in lesions and normal-appearing white matter (NAWM) in the entire brain from patients with mildly disabling relapsing-remitting multiple sclerosis (MS), (2) to compare the D of NAWM from patients with that of white matter from normal controls, (3) to evaluate whether lesions classified on the basis of their appearance on enhanced T1-weighted scans have… CONTINUE READING
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