A quantitative structure-activity relationship for antitumor activity of long-chain phenols from Ginkgo biloba L.

@article{Itokawa1989AQS,
  title={A quantitative structure-activity relationship for antitumor activity of long-chain phenols from Ginkgo biloba L.},
  author={Hideji Itokawa and N Totsuka and Keisuke Nakahara and M Maezuru and Koichi Takeya and Mamiko Kondo and Mutsumi Inamatsu and Hiroyuki Morita},
  journal={Chemical & pharmaceutical bulletin},
  year={1989},
  volume={37 6},
  pages={1619-21}
}
With the aim of obtaining compounds with strong antitumor activity, a quantitative structure-activity relationship (QSAR) of antitumor phenolic compounds (long-chain phenols) was derived using the Hansch-Fujita equation. The ED50 values against Chinese hamster V-79 cells were analyzed in terms of log P as the hydrophobic parameter and the energy of the lowest unoccupied molecular orbital (ELUMO) calculated by using the modified neglect of differential overlap (MNDO) method as the electronic… CONTINUE READING