A quantitative proteomic approach to prion disease biomarker research: delving into the glycoproteome.

@article{Wei2011AQP,
  title={A quantitative proteomic approach to prion disease biomarker research: delving into the glycoproteome.},
  author={Xin Wei and Allen Herbst and Di Ma and Judd Aiken and Lingjun Li},
  journal={Journal of proteome research},
  year={2011},
  volume={10 6},
  pages={2687-702}
}
Mass spectrometry (MS) -- based proteomic approaches have evolved as powerful tools for the discovery of biomarkers. However, the identification of potential protein biomarkers from biofluid samples is challenging because of the limited dynamic range of detection. Currently there is a lack of sensitive and reliable premortem diagnostic test for prion diseases. Here, we describe the use of a combined MS-based approach for biomarker discovery in prion diseases from mouse plasma samples. To… CONTINUE READING