A quantitative phenytoin GC-MS method and its validation for samples from human ex situ brain microdialysis, blood and saliva using solid-phase extraction.

@article{Hsli2013AQP,
  title={A quantitative phenytoin GC-MS method and its validation for samples from human ex situ brain microdialysis, blood and saliva using solid-phase extraction.},
  author={Raphael H{\"o}sli and Andrea Tobler and Stefan K{\"o}nig and Stefan M{\"u}hlebach},
  journal={Journal of analytical toxicology},
  year={2013},
  volume={37 2},
  pages={102-9}
}
This study describes the development and validation of a gas chromatography-mass spectrometry (GC-MS) method to identify and quantitate phenytoin in brain microdialysate, saliva and blood from human samples. A solid-phase extraction (SPE) was performed with a nonpolar C8-SCX column. The eluate was evaporated with nitrogen (50°C) and derivatized with… CONTINUE READING