A quantitative molecular model for modulation of mammalian translation by the eIF4E-binding protein 1.

@article{Karim2001AQM,
  title={A quantitative molecular model for modulation of mammalian translation by the eIF4E-binding protein 1.},
  author={Md. Monjurul Karim and Jacqueline M Hughes and Jim Warwicker and Gert C. Scheper and Christopher G Proud and John G. McCarthy},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 23},
  pages={20750-7}
}
Translation initiation is a key point of regulation in eukaryotic gene expression. 4E-binding proteins (4E-BPs) inhibit initiation by blocking the association of eIF4E with eIF4G, two integral components of the mRNA cap-binding complex. Phosphorylation of 4E-BP1 reduces its ability to bind to eIF4E and thereby to compete with eIF4G. A novel combination of… CONTINUE READING