A quantitative model of nucleosome dynamics

@inproceedings{Forties2011AQM,
  title={A quantitative model of nucleosome dynamics},
  author={Robert A. Forties and Justin A. North and Sarah Javaid and Omar P. Tabbaa and Richard Fishel and Michael G Poirier and Ralf Bundschuh},
  booktitle={Nucleic acids research},
  year={2011}
}
The expression, replication and repair of eukaryotic genomes require the fundamental organizing unit of chromatin, the nucleosome, to be unwrapped and disassembled. We have developed a quantitative model of nucleosome dynamics which provides a fundamental understanding of these DNA processes. We calibrated this model using results from high precision single molecule nucleosome unzipping experiments, and then tested its predictions for experiments in which nucleosomes are disassembled by the DNA… CONTINUE READING

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