A quantitative microbial risk assessment model for Legionnaires' disease: animal model selection and dose-response modeling.

@article{Armstrong2007AQM,
  title={A quantitative microbial risk assessment model for Legionnaires' disease: animal model selection and dose-response modeling.},
  author={Thomas W. Armstrong and Charles N. Haas},
  journal={Risk analysis : an official publication of the Society for Risk Analysis},
  year={2007},
  volume={27 6},
  pages={1581-96}
}
Legionnaires' disease (LD), first reported in 1976, is an atypical pneumonia caused by bacteria of the genus Legionella, and most frequently by L. pneumophila (Lp). Subsequent research on exposure to the organism employed various animal models, and with quantitative microbial risk assessment (QMRA) techniques, the animal model data may provide insights on human dose-response for LD. This article focuses on the rationale for selection of the guinea pig model, comparison of the dose-response… CONTINUE READING
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