A quantitative method to detect fucoidan in human plasma using a novel antibody.

@article{Irhimeh2005AQM,
  title={A quantitative method to detect fucoidan in human plasma using a novel antibody.},
  author={Mohammad R Irhimeh and Janet Helen Fitton and Ray M. Lowenthal and Prachya Kongtawelert},
  journal={Methods and findings in experimental and clinical pharmacology},
  year={2005},
  volume={27 10},
  pages={
          705-10
        }
}
We have developed an antibody-based method to assess plasma uptake of a proprietary Undaria-derived fucoidan galactofucan sulfate (GFS(TM)) after oral ingestion by human volunteers. Fucoidans have high-molecular-weights but exert biological effects in experimental animals after oral intake. By using a novel antibody raised against sulfated polysaccharides, we carried out a competitive ELISA to quantitate GFS in plasma samples from healthy volunteers who ingested 3 g/day of whole Undaria… Expand

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