A quantitative method for the selective 5-HT2A agonist 25CN-NBOH in rat plasma and brain.

@article{Breusova2021AQM,
  title={A quantitative method for the selective 5-HT2A agonist 25CN-NBOH in rat plasma and brain.},
  author={Kateryna Breusova and Kristian Goldeman Ernstsen and Mikael Palner and Kristian Linnet and Jesper L. Kristensen and Andreas Christopher Kretschmann},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={2021},
  volume={199},
  pages={
          114016
        }
}
3 Citations
25CN‐NBOH: A Selective Agonist for in vitro and in vivo Investigations of the Serotonin 2A Receptor
TLDR
25CN‐NBOH has been used to investigate the effects of selective 5‐HT2AR activation in vivo, and has thus become an important pharmacological tool for the exploration of 5‐ HT2AR signaling in a range of animal models.
Molecular and Functional Imaging Studies of Psychedelic Drug Action in Animals and Humans
TLDR
There remains considerable scope for basic imaging research on the sites of interaction of hallucinogens and their cerebrometabolic effects; it is expected that hybrid imaging with PET in conjunction with functional magnetic resonance imaging (fMRI) should provide especially useful for the next phase of this research.
A cluster of 25B-NBOH poisonings following exposure to powder sold as lysergic acid diethylamide (LSD).
TLDR
Exposure to 25B-NBOH in a powdered form produced sympathomimetic toxicity, including hallucinations, which led to rapid onset of status epilepticus in one case and severe clinical toxicity documented in all cases resolved within 12 h.

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