A quantitative method for measuring antipsoriatic activity of drugs by the mouse tail test.

@article{Bosman1992AQM,
  title={A quantitative method for measuring antipsoriatic activity of drugs by the mouse tail test.},
  author={Ben Bosman and Th. Matthiesen and Vincent Hess and Elmar Friderichs},
  journal={Skin pharmacology : the official journal of the Skin Pharmacology Society},
  year={1992},
  volume={5 1},
  pages={
          41-8
        }
}
Topical treatment of the mouse tail with antipsoriatic drugs enhances orthokeratotic cell differentiation in the epidermal scales. We developed a new evaluation system for this test which allows quantification of drug efficacy. Drugs were applied topically, once daily, 5 times a week, for 2 weeks. Two hours after the last treatment the animals were sacrificed, longitudinal sections of the tail skin were made and prepared for histological examination (hematoxylin-eosin staining). As indicator of… CONTINUE READING
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