A quantitative chemical proteomics approach to profile the specific cellular targets of andrographolide, a promising anticancer agent that suppresses tumor metastasis.

@article{Wang2014AQC,
  title={A quantitative chemical proteomics approach to profile the specific cellular targets of andrographolide, a promising anticancer agent that suppresses tumor metastasis.},
  author={Jigang Wang and Xing Fei Tan and Van Sang Nguyen and Peng Yang and Jing Zhou and Mingming Gao and Zhengjun Li and Teck Kwang Lim and Yingke He and Chye Sun Ong and Yifei Lay and Jianbin Zhang and Guili Zhu and Siew-Li Lai and Dipanjana Ghosh and Yu Keung Mok and H M Shen and Qingsong Lin},
  journal={Molecular & cellular proteomics : MCP},
  year={2014},
  volume={13 3},
  pages={876-86}
}
Drug target identification is a critical step toward understanding the mechanism of action of a drug, which can help one improve the drug's current therapeutic regime and expand the drug's therapeutic potential. However, current in vitro affinity-chromatography-based and in vivo activity-based protein profiling approaches generally face difficulties in discriminating specific drug targets from nonspecific ones. Here we describe a novel approach combining isobaric tags for relative and absolute… CONTINUE READING
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