A quantitative assessment of models for voltage-dependent gating of ion channels.

@article{Grabe2004AQA,
  title={A quantitative assessment of models for voltage-dependent gating of ion channels.},
  author={Michael Grabe and Harold Lecar and Yuh Nung Jan and Lily Yeh Jan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 51},
  pages={17640-5}
}
Voltage-gated ion channels open and close, or "gate," in response to changes in membrane potential. The electric field across the membrane-protein complex exerts forces on charged residues driving the channel into different functional conformations as the membrane potential changes. To act with the greatest sensitivity, charged residues must be positioned at key locations within or near the transmembrane region, which requires desolvating charged groups, a process that can be energetically… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 29 extracted citations

References

Publications referenced by this paper.

The Fokker–Planck Equation (Springer, New York)

  • H. Risken
  • 1989
1 Excerpt

Similar Papers

Loading similar papers…