A quantitative assay for JAK2(V617F) mutation in myeloproliferative disorders by ARMS-PCR and capillary electrophoresis.

@article{Vannucchi2006AQA,
  title={A quantitative assay for JAK2(V617F) mutation in myeloproliferative disorders by ARMS-PCR and capillary electrophoresis.},
  author={Alessandro Maria Vannucchi and Alessandro Pancrazzi and Costanza Bogani and Elisabetta Antonioli and Paola Guglielmelli},
  journal={Leukemia},
  year={2006},
  volume={20 6},
  pages={
          1055-60
        }
}
A point mutation in the Janus tyrosine kinase 2 (JAK2) gene has been described in patients with chronic myeloproliferative disorders (MPD), but the clinical significance of JAK2(V617F), which may be harbored in either the heterozygote or homozyote status, is still largely undefined. There are indirect suggestions that clinical phenotype and also some biological characteristics are dependent on the mutated allele levels. We have designed and validated in 179 MPD patients an amplification… CONTINUE READING

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