A quantitative approach to the design of antitumor drug dosage schedule via cell cycle kinetics and systems theory

@article{Kim1977AQA,
  title={A quantitative approach to the design of antitumor drug dosage schedule via cell cycle kinetics and systems theory},
  author={M. Kim and Kwang Bang Woo and Seymour Perry},
  journal={Annals of Biomedical Engineering},
  year={1977},
  volume={5},
  pages={12-33}
}
A discrete-time kinetic model for chemotherapy was developed to deal with the effects of antitumor drugs on the cell cycle and proliferation kinetics of experimental tumor cell populations in which cell kinetic responses of chemotherapy are represented in terms of perturbation of cell kinetic parameters—cell age, cell size and DNA content distributions. The time-course behavior of these cell kinetic parameters was predicted by solving the discrete-time state equations which characterize the… CONTINUE READING

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