A quantitative approach to hepatic clearance prediction of metabolism by aldehyde oxidase using custom pooled hepatocytes.

@article{Akabane2012AQA,
  title={A quantitative approach to hepatic clearance prediction of metabolism by aldehyde oxidase using custom pooled hepatocytes.},
  author={Takafumi Akabane and Nicolas Gerst and Jeffrey Masters and Kouichi Tamura},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={2012},
  volume={42 9},
  pages={863-71}
}
We describe the usability of human pooled hepatocytes for non-CYP metabolism evaluation and an in vivo-in vitro correlation analysis for aldehyde oxidase (AO) substrate compounds using pooled hepatocytes. By comparing intrinsic clearance values of 18 compounds primarily metabolized by AO, UDP-glucuronosyltransferase, carbonyl/aldo-keto reductase, flavin-containing monooxygenase, and monoamineoxidase in individual hepatocytes and pooled hepatocytes from the same individual donors, intrinsic… CONTINUE READING
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