A quantitative and cytological study of germ cells in human ovaries

@article{Baker1963AQA,
  title={A quantitative and cytological study of germ cells in human ovaries},
  author={Terry G. Baker},
  journal={Proceedings of the Royal Society of London. Series B. Biological Sciences},
  year={1963},
  volume={158},
  pages={417 - 433}
}
  • T. G. Baker
  • Published 22 October 1963
  • Biology
  • Proceedings of the Royal Society of London. Series B. Biological Sciences
Foetal, neonatal and post-natal human ovaries (2 months p.c. to 7 years p.p.) were studied with the object of correlating cytological changes in the germ cells with fluctuations in their numbers. The chromosomal configurations of oogonia and oocytes were examined in both histological and squash preparations. The numbers of normal and degenerating germ cells at different developmental stages up to the time of birth were estimated volumetrically, while those in post-natal ovaries were assessed by… 

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References

SHOWING 1-10 OF 30 REFERENCES
A quantitative and cytological study of oogonia and oocytes in the foetal and neonatal rat
  • H. Beaumont, A. Mandl
  • Biology
    Proceedings of the Royal Society of London. Series B. Biological Sciences
  • 1962
TLDR
The ovaries of foetal and neonatal rats have been studied in order to correlate morphological changes in oogonia and developing oocytes with fluctuations in their numbers and to estimate the populations of normal and degenerating germ cells.
Oogenesis in the mouse. A study of the meiotic prophase.
  • K. Borum
  • Biology, Medicine
    Experimental cell research
  • 1961
TLDR
In albino mice of the street strain ovaries from the 10th day of fetal life until the 5th day after birth the ovaries were studied histologically and cytologically by the squash technique to find out the pattern of oogenesis.
The ultrastructure of oogonia and oocytes in the foetal and neonatal rat
  • L. L. Franchi, A. Mandl
  • Biology
    Proceedings of the Royal Society of London. Series B. Biological Sciences
  • 1962
TLDR
Ovaries from eighty foetal and neonatal rats were examined under the electron microscope and patterns of degeneration (‘atretic divisions’, ‘Z’ cells and atresia at the diplotene phase), whose histological appearance and incidence have been recorded by Beaumont & Mandl (1962), were identified.
The numbers of normal and atretic ova in the mature rat.
TLDR
There is no consensus about the part played by the germinal epithelium in oogenesis, nor is it established beyond dispute that oocytes continue to be produced throughout the reproductive life of an animal, but general view is that the number of oocytes in an ovary varies systematically with the phases of the cycle.
X-chromosome behavior in germ and somatic cells of Rattus norvegicus.
TLDR
Follicular cells, on the other hand, demonstrate a distinct characteristic of female somatic cells from the earliest stage of gonadal development; namely, formation of the sex chromatin by a single X-chromosome in positive heteropycnosis.
Pre-ovulatory changes in the oocyte of the adult rat
  • A. Mandl
  • Biology
    Proceedings of the Royal Society of London. Series B. Biological Sciences
  • 1963
TLDR
The sequence of nuclear changes in the oocyte of the adult rat has been investigated, with particular emphasis on early pre-ovulatory stages, and an attempt made to determine the time at which diakinesis occurs.
The Development in vitro of the Mammalian Gonad. Ovary and Ovogenesis
Several investigators have tried to cultivate in vitro the mammalian and avian gonad, usually with the object of obtaining the growth and differentiation of the germ cells under in vitro conditions.
Female germ cells of man.
TLDR
It has been concluded that in females, positive heteropycnosis of one of the two X-chromosomes, resulting in formation of the sex chromatin body, is characteristic of somatic cells but not of germ cells in those mammalian species observed.
Meiotic Prophase in Female Mice
TLDR
It was found that in all strains the oogonial nuclei in newly born females are without exception in the resting stage probably following the last mitotic division.
The Pachytene Stage in Mammalian Oocytes
TLDR
There is a great need for a more precise method of identification by which individual chromosomes can be recognized.
...
1
2
3
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