A quantitative and comparative study of the effects of a synthetic ciguatoxin CTX3C on the kinetic properties of voltage-dependent sodium channels.

@article{Yamaoka2004AQA,
  title={A quantitative and comparative study of the effects of a synthetic ciguatoxin CTX3C on the kinetic properties of voltage-dependent sodium channels.},
  author={Kaoru Yamaoka and Masayuki Inoue and Hidemichi Miyahara and Keisuke Miyazaki and Masahiro Hirama},
  journal={British journal of pharmacology},
  year={2004},
  volume={142 5},
  pages={
          879-89
        }
}
Ciguatoxins (CTXs) are known to bind to receptor site 5 of the voltage-dependent Na channel, but the toxin's physiological effects are poorly understood. In this study, we investigated the effects of a ciguatoxin congener (CTX3C) on three different Na-channel isoforms, rNa(v)1.2, rNa(v)1.4, and rNa(v)1.5, which were transiently expressed in HEK293 cells. The toxin (1.0 micromol l(-1)) shifted the activation potential (V(1/2) of activation curve) in the negative direction by 4-9 mV and increased… CONTINUE READING
BETA

Topics from this paper.

Citations

Publications citing this paper.

Similar Papers

Loading similar papers…