A quantitative analysis of the variables affecting the repertoire of T cell specificities recognized after vaccinia virus infection.

@article{Assarsson2007AQA,
  title={A quantitative analysis of the variables affecting the repertoire of T cell specificities recognized after vaccinia virus infection.},
  author={Erika Assarsson and John Sidney and Carla Oseroff and Val{\'e}rie Pasquetto and Huynh-Hoa Bui and Nicole Frahm and Christian Brander and Bjoern Peters and Howard Grey and Alessandro Sette},
  journal={Journal of immunology},
  year={2007},
  volume={178 12},
  pages={7890-901}
}
Many components contribute to immunodominance in the response to a complex virus, but their relative importance is unclear. This was addressed using vaccinia virus and HLA-A*0201 as the model system. A comprehensive analysis of 18 viral proteins recognized by CD8(+) T cell responses demonstrated that approximately one-fortieth of all possible 9- to 10-mer peptides were high-affinity HLA-A*0201 binders. Peptide immunization and T cell recognition data generated from 90 peptides indicated that… CONTINUE READING
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