A quantitative analysis of the kinetics of the G(2) DNA damage checkpoint system.

@article{Aguda1999AQA,
  title={A quantitative analysis of the kinetics of the G(2) DNA damage checkpoint system.},
  author={Baltazar D. Aguda},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 20},
  pages={11352-7}
}
  • Baltazar D. Aguda
  • Published 1999 in
    Proceedings of the National Academy of Sciences…
A detailed model of the G(2) DNA damage checkpoint (G2DDC) system is presented that includes complex regulatory networks of the mitotic kinase Cdc2, phosphatase Cdc25, Wee1 kinase, and damage signal transduction pathways involving Chk1 and p53. Assumptions on the kinetic equations of the G2DDC are made, and computer simulations are carried out to demonstrate how the various subsystems operate to delay or arrest cell cycle progression. The detailed model could be used to explain various… CONTINUE READING
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Aguda Proc

  • Hindmarsch, 15 A.C.ACMSignumNewslett., 10. Cell Biology
  • Natl. Acad. Sci. USA 96
  • 1999
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ACM Signum Newslett . 15 , 10

  • A. C. Hindmarsch
  • 1980

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