A quantitative analysis of kinase inhibitor selectivity

Abstract

Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity are poorly defined, and an important step toward understanding the relationship between selectivity, efficacy and safety is the exploration of how inhibitors interact with the human kinome. We present… (More)
DOI: 10.1038/nbt1358

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