A quantitative alternative to the hysteresis plot for measurement of drug transit time.

Abstract

INTRODUCTION Hysteresis plots can be used to examine pharmacokinetic data in which there is a transport delay between drug concentrations at two sites in the body (e.g., in blood entering and leaving an organ). However, the area enclosed by the hysteresis "loop" does not provide quantitative information about the magnitude of the delay. METHODS A quick… (More)

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