A quantitative account of the activation steps involved in phototransduction in amphibian photoreceptors.

@article{Lamb1992AQA,
  title={A quantitative account of the activation steps involved in phototransduction in amphibian photoreceptors.},
  author={T. D. Lamb and E. N. Pugh},
  journal={The Journal of physiology},
  year={1992},
  volume={449},
  pages={719-58}
}
1. We have undertaken a theoretical analysis of the steps contributing to the phototransduction cascade in vertebrate photoreceptors. We have explicitly considered only the activation steps, i.e. we have not dealt with the inactivation reactions. 2. From the theoretical analysis we conclude that a single photoisomerization leads to activation of the phosphodiesterase (PDE) with a time course which approximates a delayed ramp; the delay is contributed by several short first-order delay stages. 3… CONTINUE READING
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