A quantitative MR imaging assessment of leukoencephalopathy in children treated for acute lymphoblastic leukemia without irradiation.

@article{Reddick2005AQM,
  title={A quantitative MR imaging assessment of leukoencephalopathy in children treated for acute lymphoblastic leukemia without irradiation.},
  author={Wilburn E. Reddick and John O. Glass and Kathleen J. Helton and James William Langston and C Li and Ching-Hon Pui},
  journal={AJNR. American journal of neuroradiology},
  year={2005},
  volume={26 9},
  pages={2371-7}
}
PURPOSE Intravenous methotrexate (IV-MTX), an effective treatment for acute lymphoblastic leukemia (ALL), has a significant toxic effect on the central nervous system, with leukoencephalopathy (LE) being the most common form. The purpose of this study was to use objective quantitative MR imaging to prospectively assess the temporal evolution of LE extent and intensity. METHODS Forty-five children (low-risk, 10 mol/L/12F; mean age, 5.0 years at diagnosis; standard/high-risk, 11 mol/L/12F; mean… CONTINUE READING

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