A qualitative quantum rate model for hydrogen transfer in soybean lipoxygenase.

  title={A qualitative quantum rate model for hydrogen transfer in soybean lipoxygenase.},
  author={Srdjan Jevtic and Jennifer Anders},
  journal={The Journal of chemical physics},
  volume={147 11},
The hydrogen transfer reaction catalysed by soybean lipoxygenase (SLO) has been the focus of intense study following observations of a high kinetic isotope effect (KIE). Today high KIEs are generally thought to indicate departure from classical rate theory and are seen as a strong signature of tunnelling of the transferring particle, hydrogen or one of its isotopes, through the reaction energy barrier. In this paper, we build a qualitative quantum rate model with few free parameters that… 

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  • E. Pollak
  • Biology
    The journal of physical chemistry. B
  • 2012
It is suggested that variational transition state theory as applied to dissipative systems, above the crossover temperature between deep tunneling and thermal activation, may be used as a paradigm for understanding the dynamics of these reactions.