A qualitative PCR minipool strategy to screen for virologic failure and antiretroviral drug resistance in South African patients on first-line antiretroviral therapy.

@article{Newman2014AQP,
  title={A qualitative PCR minipool strategy to screen for virologic failure and antiretroviral drug resistance in South African patients on first-line antiretroviral therapy.},
  author={Howard Newman and Lukas Breunig and Gert Van Zyl and August Stich and Wolfgang Preiser},
  journal={Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology},
  year={2014},
  volume={60 4},
  pages={387-91}
}
BACKGROUND The high cost of commercial HIV-1 viral load tests for monitoring of patients on antiretroviral treatment limits their use in resource-constrained settings. Commercial genotypic antiretroviral resistance testing is even more costly, yet it provides important benefits. OBJECTIVES We sought to determine the sensitivity and negative predictive value of a qualitative PCR targeting partial reverse transcriptase for detection of virologic failure when 5 patient specimens are pooled… CONTINUE READING
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