A pyrrole-imidazole polyamide targeting transforming growth factor-beta1 inhibits restenosis and preserves endothelialization in the injured artery.

@article{Yao2009APP,
  title={A pyrrole-imidazole polyamide targeting transforming growth factor-beta1 inhibits restenosis and preserves endothelialization in the injured artery.},
  author={E G Yao and Noboru Fukuda and Takahiro Ueno and Hiroyuki Matsuda and Hiroki Nagase and Yoshiaki Matsumoto and Hiroshi Sugiyama and Koichi Matsumoto},
  journal={Cardiovascular research},
  year={2009},
  volume={81 4},
  pages={797-804}
}
AIMS Although the use of drug-eluting stents (DESs) has been shown to limit neointima hyperplasia, currently available DESs may adversely affect re-endothelialization. To evaluate whether a novel gene silencer pyrrole-imidazole (PI) polyamide targeting transforming growth factor (TGF)-beta1 is a candidate agent for the DESs, we examined the effects of PI polyamide targeting the TGF-beta1 promoter on neointimal formation in rat carotid artery after balloon injury. METHODS AND RESULTS PI… CONTINUE READING
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