A pyridazine series of alpha2/alpha3 subtype selective GABA A agonists for the treatment of anxiety.

@article{Lewis2006APS,
  title={A pyridazine series of alpha2/alpha3 subtype selective GABA A agonists for the treatment of anxiety.},
  author={Richard Lewis and Wesley P Blackaby and Timothy Blackburn and Andrew S R Jennings and Andrew J. Pike and Rowan A Wilson and David J Hallett and Susan M Cook and Pushpinder Ferris and George Ryne Marshall and David W. Reynolds and Wayne F A Sheppard and Alison J. Smith and Bindi Sohal and Joanna Stanley and Spencer J. Tye and Keith A Wafford and John R. Atack},
  journal={Journal of medicinal chemistry},
  year={2006},
  volume={49 8},
  pages={2600-10}
}
The development of a series of GABA(A) alpha2/alpha3 subtype selective pyridazine based benzodiazepine site agonists as anxiolytic agents with reduced sedative/ataxic potential is described, including the discovery of 16, a remarkably alpha3-selective compound ideal for in vivo study. These ligands are antagonists at the alpha1 subtype, with good CNS penetration and receptor occupancy, and excellent oral bioavailability.