A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors.

@article{Souyri1990APT,
  title={A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors.},
  author={Mich{\`e}le Souyri and Isabelle Vigon and J F Penciolelli and Jean Michel Heard and Pierre E. Tambourin and Françoise Wendling},
  journal={Cell},
  year={1990},
  volume={63 6},
  pages={1137-47}
}
The myeloproliferative leukemia virus (MPLV) is an acute leukemogenic murine replication-defective retrovirus. By sequencing the envelope gene of a biologically active MPLV clone, we found that this region comprises a novel oncogene named v-mpl in phase with two parts of the Friend murine leukemia virus envelope gene. The MPLV env region could encode an env-mpl fusion polypeptide that presents the characteristics of a transmembrane protein. We show that in vitro infection of bone marrow cells… CONTINUE READING

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