A putative transcriptional elongation factor hIws1 is essential for mammalian cell proliferation.

@article{Liu2007APT,
  title={A putative transcriptional elongation factor hIws1 is essential for mammalian cell proliferation.},
  author={Zhangguo Liu and Zhongwei Zhou and G. Chen and S. Bao},
  journal={Biochemical and biophysical research communications},
  year={2007},
  volume={353 1},
  pages={
          47-53
        }
}
Iws1 has been implicated in transcriptional elongation by interaction with RNA polymerase II (RNAP II) and elongation factor Spt6 in budding yeast Saccharomyces cerevisiae, and association with transcription factor TFIIS in mammalian cells, but its role in controlling cell growth and proliferation remains unknown. Here we report that the human homolog of Iws1, hIws1, physically interacts with protein arginine methyltransferases PRMT5 which methylates elongation factor Spt5 and regulates its… Expand
Arabidopsis IWS1 interacts with transcription factor BES1 and is involved in plant steroid hormone brassinosteroid regulated gene expression
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