A putative stimulatory role for activator turnover in gene expression

  title={A putative stimulatory role for activator turnover in gene expression},
  author={J. Russell Lipford and Geoffrey T. Smith and Yong Hun Chi and Raymond J Deshaies},
The ubiquitin–proteasome system (UPS) promotes the destruction of target proteins by attaching to them a ubiquitin chain that is recognized by the 26S proteasome. The UPS influences most cellular processes, and its targets include transcriptional activators that are primary determinants of gene expression. Emerging evidence indicates that non-proteolytic functions of the UPS might stimulate transcriptional activity. Here we show that the proteolysis of some transcriptional activators by the UPS… CONTINUE READING

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Complementary whole-genome technologies reveal the cellular response to proteasome inhibition by PS-341.

Proceedings of the National Academy of Sciences of the United States of America • 2002

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