A putative role of p53 pathway against impulse noise induced damage as demonstrated by protection with pifithrin-alpha and a Src inhibitor

@article{Fetoni2014APR,
  title={A putative role of p53 pathway against impulse noise induced damage as demonstrated by protection with pifithrin-alpha and a Src inhibitor},
  author={Anna Rita Fetoni and Eric C. Bielefeld and G. Paludetti and Thomas M. Nicotera and Donald K. Henderson},
  journal={Neuroscience Research},
  year={2014},
  volume={81–82},
  pages={30-37}
}
Exposure to high-level noise leads to oxidative stress and triggers apoptosis of the hair cells. This study examined whether p53, a tumor suppressor protein, is activated in the cochlea following impulse noise exposure. Inhibition of p53 with pifithrin alpha, a specific p53 inhibitor, or KX1-004, a Src-protein tyrosine kinase inhibitor, was tested to determine if p53 inhibition could reduce noise-induced hearing loss and cochlear damage. Chinchillas were pre-treated with a local administration… CONTINUE READING

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