A putative role for apelin in the etiology of obesity.

@article{Rayalam2008APR,
  title={A putative role for apelin in the etiology of obesity.},
  author={Srujana Rayalam and Mary Anne Della-Fera and Paul A. Krieg and Christopher M. Cox and Allan Robins and Clifton A. Baile},
  journal={Biochemical and biophysical research communications},
  year={2008},
  volume={368 3},
  pages={815-9}
}
Apelin, the endogenous ligand of the G protein-coupled APJ receptor has been shown to promote tumor angiogenesis. However, the effect of apelin on inducing angiogenesis in adipose tissue has not been investigated. In this review, we propose a putative role for apelin in promoting angiogenesis in adipose tissue. We further propose that targeting adipose tissue vasculature by blocking apelin signaling with anti-apelin antibodies will lead not only to inhibition of angiogenesis in adipose tissue… CONTINUE READING

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