A putative prokaryote voltage-gated Ca(2+) channel with only one 6TM motif per subunit.

@article{Durell2001APP,
  title={A putative prokaryote voltage-gated Ca(2+) channel with only one 6TM motif per subunit.},
  author={Stewart R Durell and H. Robert Guy},
  journal={Biochemical and biophysical research communications},
  year={2001},
  volume={281 3},
  pages={741-6}
}
Until now, voltage-gated Ca(2+) channel proteins have been found only in eukaryotes. Here we report that a gene recently discovered in the eubacterium Bacillus halodurans codes for a protein closely related to eukaryotic Ca(2+) channels, but that has only one 6-transmembrane-segement (6TM) motif, instead of four, in its pore-forming subunit. This is supported by the comparison of consensus sequences, which, along with the patterns of residue conservation, indicates a similar structure in the… CONTINUE READING