A putative pH-dependent nuclear localization signal in the juxtamembrane region of c-Met

Abstract

The C-terminal fragment of the c-Met receptor tyrosine kinase is present in the nuclei of some cells irrespective of ligand stimulation, but the responsible nuclear localization signal (NLS) has not been previously reported. Here, we report that two histidine residues separated by a 10-amino-acid spacer (H1068–H1079) located in the juxtamembrane region of c… (More)
DOI: 10.1038/emm.2014.67

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