426 Citations
12 Phospo-PKCs in Abeta 1-42-Specific Human T Cells from Alzheimer ’ s Disease Patients
- Biology
- 2017
It has been demonstrated that a subset of Amyloid-Beta1-42-specific Tcells, characterised by bright expression of Phosphorylated-Protein-Kinase C, distinguishes Alzheimer’s Disease from other neurodegenerative conditions.
PI3K: from the bench to the clinic and back.
- BiologyCurrent topics in microbiology and immunology
- 2010
PI3K has become a very intense area of research, with over 2,000 publications on PI3K in PubMed for 2009 alone and progress in the clinical arena is being monitored by many.
Spectrin, alpha-actinin, and dystrophin.
- BiologyAdvances in protein chemistry
- 2005
A comparative proteomics resource: proteins of Arabidopsis thaliana
- BiologyGenome Biology
- 2003
All the proteins of Arabidopsis thaliana are analyzed and three-dimensional structures at the level of the domain are assigned by fold recognition and threading based on a novel fold library that extends common domain classifications.
SPTBN5, Encoding the βV-Spectrin Protein, Leads to a Syndrome of Intellectual Disability, Developmental Delay, and Seizures
- MedicineFrontiers in Molecular Neuroscience
- 2022
The SPTBN5-associated clinical traits in patients include intellectual disability (mild to severe), aggressive tendencies, accompanied by variable features such as craniofacial and physical dysmorphisms, autistic behavior, and gastroesophageal reflux.
From DEPARTMENT OF MEDICINE, SOLNA Karolinska Institutet, Stockholm, Sweden PROMOTER MUTATIONS/METHYLATION IN THYROID AND UROTHELIAL CARCINOMAS: BIOLOGICAL AND CLINICAL IMPLICATIONS
- Biology
- 2021
The present thesis demonstrated how mutations or aberrant DNA methylation of TERT, GABPB1, PLEKHS1 and GPR126 genes occur in TC and UTUC, and how these events interact together or function independently to participate in TC or UTUC pathogenesis.
PLEKHA7 signaling is necessary for the growth of mutant KRAS driven colorectal cancer.
- BiologyExperimental cell research
- 2021
StAR-Related Lipid Transfer (START) Domains Across the Rice Pangenome Reveal How Ontogeny Recapitulated Selection Pressures During Rice Domestication
- BiologyFrontiers in Genetics
- 2021
The findings provide evidence for high conservation of START genes across rice varieties in numbers, as well as in their stringent regulation of Ka/Ks ratio, and showed strong functional dependency of plants on START proteins for their growth and reproductive development.
Pleckstrin-2 as a Prognostic Factor and Mediator of Gastric Cancer Progression
- Biology, MedicineGastroenterology research and practice
- 2021
It is demonstrated that PLEK2 plays a potential role in Gastric cancer and may be a novel therapeutic target for gastric cancer.
References
SHOWING 1-10 OF 12 REFERENCES
Molecular cloning of two types of GAP complementary DNA from human placenta.
- BiologyScience
- 1988
The ras p21 GTPase-activating protein (GAP) was purified from human placental tissue and internal amino acid sequence was obtained and, by means of this sequence, two types of complementary DNA clones were isolated and characterized.
SEC7 encodes an unusual, high molecular weight protein required for membrane traffic from the yeast Golgi apparatus.
- BiologyThe Journal of biological chemistry
- 1988
Use of a screen for synthetic lethal and multicopy suppressee mutants to identify two new genes involved in morphogenesis in Saccharomyces cerevisiae.
- BiologyMolecular and cellular biology
- 1991
Both bem1 and bem2 mutations cause cells to become large and multinucleate even during growth at 23 degrees C, suggesting that these genes are involved in bud emergence.
A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region.
- Biology, Computer ScienceScience
- 1991
Sequence analysis of v-akt and biochemical characterization of its product revealed that it codes for a protein kinase C-related serine-threonine kinase whose cellular homolog is expressed in most tissues, with the highest amount found in thymus, suggesting that Akt may form a functional link between tyrosine and serinesine phosphorylation pathways.
Identification of a protein that binds to the SH3 region of Abl and is similar to Bcr and GAP-rho.
- BiologyScience
- 1992
The 3BP-1 protein may be a mediator of SH3 function in transformation inhibition and may link tyrosine kinases to Ras-related proteins.
Identification of a ten-amino acid proline-rich SH3 binding site.
- BiologyScience
- 1993
Identification of the SH3 binding site provides a basis for understanding the interaction between the SH2 and SH3 domains and their targets.
Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21
- BiologyNature
- 1992
The cloning of complementary DNAs from a rat brain library that encode a ∼140 GRF for Ras p21 (p140Ras-GRF) is reported, which accelerated the release of GDP from RasH and RasN p21 in vitro, but not from the related RalA, or CDC42Hs GTP-binding proteins.